If you're weighing one GLP-1 against another, you deserve a comparison from someone with nothing to sell. This section lines up the options — semaglutide versus tirzepatide, brand versus compounded — on the dimensions that actually matter: how they work, what the trials show, and how their side effects differ. Every figure is attributed to a named trial or label, and we recommend no specific product or vendor.
Comparisons
- Semaglutide vs tirzepatide side effects — a side-by-side of what each tends to cause, and how often.
- Semaglutide vs tirzepatide: efficacy and trials — what STEP, SUSTAIN, SURMOUNT, and SURPASS reported (page in progress).
- Brand vs compounded semaglutide — what compounding is, and the real safety considerations (page in progress).
How we compare
We use class and generic names first, attribute every efficacy and safety figure to its trial or FDA label, and present trade-offs honestly rather than crowning a "winner." Compounded products are described factually — including that they are not FDA-approved finished products — without recommending or discouraging any specific vendor.
General information, not medical advice. The right medication for you is a decision for you and your prescriber.
Every clinical claim above is cited inline to a primary source. See how we review and our sourcing & fact-check standards.